Synthesis of Barbaralones and Bullvalenes Made Easy by Gold Catalysis.
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ABSTRACT:
SUBMITTER: Ferrer S
PROVIDER: S-EPMC5132030 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
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Synthesis of Barbaralones and Bullvalenes Made Easy by Gold Catalysis.
Ferrer Sofia S Echavarren Antonio M AM
Angewandte Chemie (International ed. in English) 20160819 37
The gold(I)-catalyzed oxidative cyclization of 7-ethynyl-1,3,5-cycloheptatrienes gives 1-substituted barbaralones in a general manner, which simplifies the access to other fluxional molecules. As an example, we report the shortest syntheses of bullvalene, phenylbullvalene, and disubstituted bullvalenes, and a readily accessible route to complex cage-type structures by further gold(I)-catalyzed reactions. ...[more]
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