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Posttranslational control of the scaffold for Fe-S cluster biogenesis as a compensatory regulatory mechanism.

ABSTRACT: Though toxic in excess, iron is vital for life. Thus, its use in all cells is tightly regulated. Analysis of Saccharomyces cerevisiae, which has been used extensively as a model system, has revealed layers of regulation of cellular iron trafficking and utilization. This regulation is based on the availability of both elemental iron and functionality of the Fe-S cluster biogenesis system. Here, we discuss a possible "first responder" regulatory mechanism centered on the stability of the scaffold protein on which Fe-S clusters are built.

SUBMITTER: Ciesielski SJ

PROVIDER: S-EPMC5133177 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Posttranslational control of the scaffold for Fe-S cluster biogenesis as a compensatory regulatory mechanism.

Ciesielski Szymon J SJ Craig Elizabeth A EA

Current genetics 20160531 1

Though toxic in excess, iron is vital for life. Thus, its use in all cells is tightly regulated. Analysis of Saccharomyces cerevisiae, which has been used extensively as a model system, has revealed layers of regulation of cellular iron trafficking and utilization. This regulation is based on the availability of both elemental iron and functionality of the Fe-S cluster biogenesis system. Here, we discuss a possible "first responder" regulatory mechanism centered on the stability of the scaffold ...[more]

PMID: 27246605

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