Posttranslational control of the scaffold for Fe-S cluster biogenesis as a compensatory regulatory mechanism.

ABSTRACT: Though toxic in excess, iron is vital for life. Thus, its use in all cells is tightly regulated. Analysis of Saccharomyces cerevisiae, which has been used extensively as a model system, has revealed layers of regulation of cellular iron trafficking and utilization. This regulation is based on the availability of both elemental iron and functionality of the Fe-S cluster biogenesis system. Here, we discuss a possible "first responder" regulatory mechanism centered on the stability of the scaffold protein on which Fe-S clusters are built.

SUBMITTER: Ciesielski SJ 

PROVIDER: S-EPMC5133177 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature