Aldehyde dehydrogenase is used by cancer cells for energy metabolism.
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ABSTRACT:
SUBMITTER: Kang JH
PROVIDER: S-EPMC5133370 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Aldehyde dehydrogenase is used by cancer cells for energy metabolism.
Kang Joon Hee JH Lee Seon-Hyeong SH Hong Dongwan D Lee Jae-Seon JS Ahn Hee-Sung HS Ahn Ju-Hyun JH Seong Tae Wha TW Lee Chang-Hun CH Jang Hyonchol H Hong Kyeong Man KM Lee Cheolju C Lee Jae-Ho JH Kim Soo-Youl SY
Experimental & molecular medicine 20161125 11
We found that non-small-cell lung cancer (NSCLC) cells express high levels of multiple aldehyde dehydrogenase (ALDH) isoforms via an informatics analysis of metabolic enzymes in NSCLC and immunohistochemical staining of NSCLC clinical tumor samples. Using a multiple reaction-monitoring mass spectrometry analysis, we found that multiple ALDH isozymes were generally abundant in NSCLC cells compared with their levels in normal IMR-90 human lung cells. As a result of the catalytic reaction mediated ...[more]
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