Glial pannexin1 contributes to tactile hypersensitivity in a mouse model of orofacial pain.
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ABSTRACT:
SUBMITTER: Hanstein R
PROVIDER: S-EPMC5133615 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
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Glial pannexin1 contributes to tactile hypersensitivity in a mouse model of orofacial pain.
Hanstein Regina R Hanani Menachem M Scemes Eliana E Spray David C DC
Scientific reports 20161202
Drug studies in animal models have implicated pannexin1 (Panx1) in various types of pain, including trigeminal hypersensitivity, neuropathic pain and migraine. However, the tested drugs have limited specificity and efficacy so that direct evidence for Panx1 contribution to pain has been lacking. We here show that tactile hypersensitivity is markedly attenuated by deletion of Panx1 in a mouse model of chronic orofacial pain; in this model, trigeminal ganglion Panx1 expression and function are mar ...[more]
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