Ontology highlight
ABSTRACT:
SUBMITTER: Ventham NT
PROVIDER: S-EPMC5133631 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Ventham N T NT Kennedy N A NA Adams A T AT Kalla R R Heath S S O'Leary K R KR Drummond H H Wilson D C DC Gut I G IG Nimmo E R ER Satsangi J J
Nature communications 20161125
Epigenetic alterations may provide important insights into gene-environment interaction in inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA methylation differences in 240 newly-diagnosed IBD cases and 190 controls. These include 439 differentially methylated positions (DMPs) and 5 differentially methylated regions (DMRs), which we study in detail using whole genome bisulphite sequencing. We replicate the top DMP (RPS6KA2) and DMRs (VMP1, ITGB2 and TXK) in an independent cohor ...[more]