Ontology highlight
ABSTRACT:
SUBMITTER: Huo J
PROVIDER: S-EPMC5133768 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Huo Jia J Zhang Yanfei Y Li Ruilian R Wang Yuan Y Wu Jiawen J Zhang Dingwei D
International journal of molecular sciences 20161027 11
Previous research indicates that microRNA-25 (miR-25) regulates carcinogenesis and the progression of various cancers, but the role of miR-25 in melanoma remains unclear. We observed that miR-25 was significantly upregulated in melanoma cell lines and tissue samples. Downregulation of miR-25 markedly suppressed invasion and proliferation of melanoma cells in vitro; however, overexpression of miR-25 markedly increased melanoma cell invasion and proliferation. Moreover, we observed Dickkopf-relate ...[more]