Ontology highlight
ABSTRACT:
SUBMITTER: Fiume G
PROVIDER: S-EPMC5133848 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Fiume Giuseppe G Scialdone Annarita A Rizzo Francesca F De Filippo Maria Rosaria MR Laudanna Carmelo C Albano Francesco F Golino Gaetanina G Vecchio Eleonora E Pontoriero Marilena M Mimmi Selena S Ceglia Simona S Pisano Antonio A Iaccino Enrico E Palmieri Camillo C Paduano Sergio S Viglietto Giuseppe G Weisz Alessandro A Scala Giuseppe G Quinto Ileana I
International journal of molecular sciences 20161107 11
The <i>IBTK</i> gene encodes the major protein isoform IBTKα that was recently characterized as substrate receptor of Cul3-dependent E3 ligase, regulating ubiquitination coupled to proteasomal degradation of Pdcd4, an inhibitor of translation. Due to the presence of Ankyrin-BTB-RCC1 domains that mediate several protein-protein interactions, IBTKα could exert expanded regulatory roles, including interaction with transcription regulators. To verify the effects of IBTKα on gene expression, we analy ...[more]