Transporter oligomerization: form and function.
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ABSTRACT:
SUBMITTER: Alguel Y
PROVIDER: S-EPMC5134999 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Transporter oligomerization: form and function.
Alguel Yilmaz Y Cameron Alexander D AD Diallinas George G Byrne Bernadette B
Biochemical Society transactions 20161201 6
Transporters are integral membrane proteins with central roles in the efficient movement of molecules across biological membranes. Many transporters exist as oligomers in the membrane. Depending on the individual transport protein, oligomerization can have roles in membrane trafficking, function, regulation and turnover. For example, our recent studies on UapA, a nucleobase ascorbate transporter, from Aspergillus nidulans, have revealed both that dimerization of this protein is essential for cor ...[more]
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