Dataset Information

Neighborhood socioeconomic index and stroke incidence in a national cohort of blacks and whites.

ABSTRACT:

Objective

To assess the relationship between neighborhood socioeconomic characteristics and incident stroke in a national cohort of black and white participants.

Methods

The study comprised black (n = 10,274, 41%) and white (n = 14,601) stroke-free participants, aged 45 and older, enrolled in 2003-2007 in Reasons for Geographic and Racial Differences in Stroke (REGARDS), a national population-based cohort. A neighborhood socioeconomic score (nSES) was constructed using 6 neighborhood variables. Incident stroke was defined as first occurrence of stroke over an average 7.5 (SD 3.0) years of follow-up. Proportional hazards models were used to estimate associations between nSES score and incident stroke, adjusted for demographics (age, race, sex, region), individual socioeconomic status (SES) (education, household income), and other risk factors for stroke.

Results

After adjustment for demographics, compared to the highest nSES quartile, stroke incidence increased with each decreasing nSES quartile. The hazard ratio (95% confidence interval) ranged from 1.28 (1.05-1.56) in quartile 3 to 1.38 (1.13-1.68) in quartile 2 to 1.56 (1.26-1.92) in quartile 1 (p < 0.0001 for linear trend). After adjustment for individual SES, the trend remained marginally significant (p = 0.085). Although there was no evidence of a differential effect by race or sex, adjustment for stroke risk factors attenuated the association between nSES and stroke in both black and white participants, with greater attenuation in black participants.

Conclusions

Risk of incident stroke increased with decreasing nSES but the effect of nSES is attenuated through individual SES and stroke risk factors. The effect of neighborhood socioeconomic characteristics that contribute to increased stroke risk is similar in black and white participants.

SUBMITTER: Howard VJ

PROVIDER: S-EPMC5135020 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Publications

Neighborhood socioeconomic index and stroke incidence in a national cohort of blacks and whites.

Howard Virginia J VJ McClure Leslie A LA Kleindorfer Dawn O DO Cunningham Solveig A SA Thrift Amanda G AG Diez Roux Ana V AV Howard George G

Neurology 20161014 22

<h4>Objective</h4>To assess the relationship between neighborhood socioeconomic characteristics and incident stroke in a national cohort of black and white participants.<h4>Methods</h4>The study comprised black (n = 10,274, 41%) and white (n = 14,601) stroke-free participants, aged 45 and older, enrolled in 2003-2007 in Reasons for Geographic and Racial Differences in Stroke (REGARDS), a national population-based cohort. A neighborhood socioeconomic score (nSES) was constructed using 6 neighborh ...[more]

PMID: 27742815

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Dataset Information

Neighborhood socioeconomic index and stroke incidence in a national cohort of blacks and whites.

Objective

Methods

Results

Conclusions

Publications

Neighborhood socioeconomic index and stroke incidence in a national cohort of blacks and whites.

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