Ontology highlight
ABSTRACT:
SUBMITTER: Agarwal S
PROVIDER: S-EPMC5135269 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Agarwal Shailesh S Cholok David D Loder Shawn S Li John J Breuler Christopher C Chung Michael T MT Sung Hsiao Hsin HH Ranganathan Kavitha K Habbouche Joe J Drake James J Peterson Joshua J Priest Caitlin C Li Shuli S Mishina Yuji Y Levi Benjamin B
JCI insight 20161208 20
Muscle trauma is highly morbid due to intramuscular scarring, or fibrosis, and muscle atrophy. Studies have shown that bone morphogenetic proteins (BMPs) reduce muscle atrophy. However, increased BMP signaling at muscle injury sites causes heterotopic ossification, as seen in patients with fibrodysplasia ossificans progressiva (FOP), or patients with surgically placed BMP implants for bone healing. We use a genetic mouse model of hyperactive BMP signaling to show the development of intramuscular ...[more]