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Trastuzumab in the management of gastroesophageal cancer: patient selection and perspectives.

ABSTRACT: The addition of trastuzumab to the treatment of a subset of patients with advanced gastric and gastroesophageal junction cancers showing HER2 positivity has been shown to confer clinical benefit; however, questions remain over the optimal methods for defining and selecting such patients. This review provides an overview of current standards for assessing HER2 positivity, the evolving treatment landscape for HER2-positive gastric and esophageal cancers and the challenges and potential future directions in optimal patient selection for HER2-targeted therapy.

SUBMITTER: Davidson M

PROVIDER: S-EPMC5135398 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Trastuzumab in the management of gastroesophageal cancer: patient selection and perspectives.

Davidson Michael M Starling Naureen N

OncoTargets and therapy 20161125

The addition of trastuzumab to the treatment of a subset of patients with advanced gastric and gastroesophageal junction cancers showing HER2 positivity has been shown to confer clinical benefit; however, questions remain over the optimal methods for defining and selecting such patients. This review provides an overview of current standards for assessing HER2 positivity, the evolving treatment landscape for HER2-positive gastric and esophageal cancers and the challenges and potential future dire ...[more]

PMID: 27932891

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Dataset Information

Trastuzumab in the management of gastroesophageal cancer: patient selection and perspectives.

Publications

Trastuzumab in the management of gastroesophageal cancer: patient selection and perspectives.

Similar Datasets

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