Ontology highlight
ABSTRACT:
SUBMITTER: Burvenich IJ
PROVIDER: S-EPMC5135445 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Burvenich Ingrid J G IJ Lee Fook-Thean FT Guo Nancy N Gan Hui K HK Rigopoulos Angela A Parslow Adam C AC O'Keefe Graeme J GJ Gong Sylvia J SJ Tochon-Danguy Henri H Rudd Stacey E SE Donnelly Paul S PS Kotsuma Masakatsu M Ohtsuka Toshiaki T Senaldi Giorgio G Scott Andrew M AM
Theranostics 20160925 12
<b>Background:</b> DS-8273a, an anti-human death receptor 5 (DR5) agonistic antibody, has cytotoxic activity against human cancer cells and induces apoptosis after specific binding to DR5. DS-8273a is currently being used in clinical Phase I trials. This study evaluated the molecular imaging of DR5 expression <i>in vivo</i> in mouse tumor models using SPECT/CT and PET/MRI, as a tool for drug development and trial design. <b>Methods:</b> DS-8273a was radiolabeled with indium-111 and zirconium-89. ...[more]