Ontology highlight
ABSTRACT:
SUBMITTER: Sentman ML
PROVIDER: S-EPMC5136298 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Sentman Marie-Louise ML Murad Joana M JM Cook W James WJ Wu Ming-Ru MR Reder Jake J Baumeister Susanne H SH Dranoff Glenn G Fanger Michael W MW Sentman Charles L CL
Journal of immunology (Baltimore, Md. : 1950) 20161114 12
Targeting cancer through the use of effector T cells bearing chimeric Ag receptors (CARs) leads to elimination of tumors in animals and patients, but recognition of normal cells or excessive activation can result in significant toxicity and even death. CAR T cells based on modified NKG2D receptors are effective against many types of tumors, and their efficacy is mediated through direct cytotoxicity and cytokine production. Under certain conditions, their ligands can be expressed on nontumor cell ...[more]