Ontology highlight
ABSTRACT:
SUBMITTER: Pieterse E
PROVIDER: S-EPMC5137018 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Pieterse Elmar E Jeremic Ivica I Czegley Christine C Weidner Daniela D Biermann Mona H C MH Veissi Susan S Maueröder Christian C Schauer Christine C Bilyy Rostyslav R Dumych Tetiana T Hoffmann Markus M Munoz Luis E LE Bengtsson Anders A AA Schett Georg G van der Vlag Johan J Herrmann Martin M
Scientific reports 20161205
Hyperuricemia is strongly linked to cardiovascular complications including atherosclerosis and thrombosis. In individuals with hyperuricemia, needle-shaped monosodium urate crystals (nsMSU) frequently form within joints or urine, giving rise to gouty arthritis or renal calculi, respectively. These nsMSU are potent instigators of neutrophil extracellular trap (NET) formation. Little is known on the mechanism(s) that prevent nsMSU formation within hyperuricemic blood, which would potentially cause ...[more]