Ontology highlight
ABSTRACT:
SUBMITTER: Sikkema-Raddatz B
PROVIDER: S-EPMC5137038 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Sikkema-Raddatz Birgit B Johansson Lennart F LF de Boer Eddy N EN Boon Elles M J EM Suijkerbuijk Ron F RF Bouman Katelijne K Bilardo Catia M CM Swertz Morris A MA Dijkstra Martijn M van Langen Irene M IM Sinke Richard J RJ Te Meerman Gerard J GJ
Scientific reports 20161205
To properly interpret the result of a pregnant woman's non-invasive prenatal test (NIPT), her a priori risk must be taken into account in order to obtain her personalised a posteriori risk (PPR), which more accurately expresses her true likelihood of carrying a foetus with trisomy. Our aim was to develop a tool for laboratories and clinicians to calculate easily the PPR for genome-wide NIPT results, using diploid samples as a control group. The tool takes the a priori risk and Z-score into accou ...[more]