Unknown

Dataset Information

0

C-MET as a Potential Therapeutic Target in Ovarian Clear Cell Carcinoma.


ABSTRACT: In this study, we investigated the therapeutic effects of c-MET inhibition in ovarian clear cell carcinoma (OCCC). Expression levels of c-MET in the epithelial ovarian cancers (EOCs) and normal ovarian tissues were evaluated using real-time PCR. To test the effects of c-MET inhibitors in OCCC cell lines, we performed MTT and apoptosis assays. We used Western blots to evaluate the expression of c-MET and its down-stream pathway. In vivo experiments were performed to test the effects of c-MET inhibitor on tumor growth in orthotopic mouse xenografts of OCCC cell line RMG1 and a patient-derived tumor xenograft (PDX) model of OCCC. c-MET expression was significantly greater in OCCCs compared with serous carcinomas and normal ovarian tissues (p?

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC5137074 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications


In this study, we investigated the therapeutic effects of c-MET inhibition in ovarian clear cell carcinoma (OCCC). Expression levels of c-MET in the epithelial ovarian cancers (EOCs) and normal ovarian tissues were evaluated using real-time PCR. To test the effects of c-MET inhibitors in OCCC cell lines, we performed MTT and apoptosis assays. We used Western blots to evaluate the expression of c-MET and its down-stream pathway. In vivo experiments were performed to test the effects of c-MET inhi  ...[more]

Similar Datasets

| S-EPMC6032401 | biostudies-literature
| S-EPMC5083746 | biostudies-literature
| S-EPMC4181630 | biostudies-other
| S-EPMC8198755 | biostudies-literature
| S-EPMC5722499 | biostudies-literature
| S-EPMC7911626 | biostudies-literature
| S-EPMC3852914 | biostudies-literature
| S-EPMC4934028 | biostudies-literature
| S-EPMC3181384 | biostudies-literature
| S-EPMC5342744 | biostudies-literature