C-MET as a Potential Therapeutic Target in Ovarian Clear Cell Carcinoma.
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ABSTRACT:
SUBMITTER: Kim HJ
PROVIDER: S-EPMC5137074 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
c-MET as a Potential Therapeutic Target in Ovarian Clear Cell Carcinoma.
Kim Ha-Jeong HJ Yoon Aera A Ryu Ji-Yoon JY Cho Young-Jae YJ Choi Jung-Joo JJ Song Sang Yong SY Bang Heejin H Lee Ji Soo JS Cho William Chi WC Choi Chel Hun CH Lee Jeong-Won JW Kim Byoung-Gie BG Bae Duk-Soo DS
Scientific reports 20161205
In this study, we investigated the therapeutic effects of c-MET inhibition in ovarian clear cell carcinoma (OCCC). Expression levels of c-MET in the epithelial ovarian cancers (EOCs) and normal ovarian tissues were evaluated using real-time PCR. To test the effects of c-MET inhibitors in OCCC cell lines, we performed MTT and apoptosis assays. We used Western blots to evaluate the expression of c-MET and its down-stream pathway. In vivo experiments were performed to test the effects of c-MET inhi ...[more]
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