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ABSTRACT:
SUBMITTER: Meekins DA
PROVIDER: S-EPMC5137461 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Meekins David A DA Zhang Xin X Battaile Kevin P KP Lovell Scott S Michel Kristin K
Acta crystallographica. Section F, Structural biology communications 20161119 Pt 12
Serine protease inhibitors (serpins) in insects function within development, wound healing and immunity. The genome of the African malaria vector, Anopheles gambiae, encodes 23 distinct serpin proteins, several of which are implicated in disease-relevant physiological responses. A. gambiae serpin 18 (SRPN18) was previously categorized as non-inhibitory based on the sequence of its reactive-center loop (RCL), a region responsible for targeting and initiating protease inhibition. The crystal struc ...[more]