Ontology highlight
ABSTRACT:
SUBMITTER: Hoffman M
PROVIDER: S-EPMC5138057 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Hoffman M M Taylor B E BE Harris M B MB
Respiratory physiology & neurobiology 20151021
Air breathing was critical to the terrestrial radiation and evolution of tetrapods and arose in fish. The vertebrate lung originated from a progenitor structure present in primitive boney fish. The origin of the neural substrates, which are sensitive to metabolically produced CO2 and which rhythmically activate respiratory muscles to match lung ventilation to metabolic demand, is enigmatic. We have found that a distinct periodic centrally generated rhythm, described as "cough" and occurring in l ...[more]