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AdoMet analog synthesis and utilization: current state of the art.

ABSTRACT: S-Adenosyl-l-methionine (AdoMet) is an essential enzyme cosubstrate in fundamental biology with an expanding range of biocatalytic and therapeutic applications. In recent years, technologies enabling the synthesis and utilization of novel functional AdoMet surrogates have rapidly advanced. Developments highlighted within this brief review include improved syntheses of AdoMet analogs, unique S-adenosyl-l-methionine isosteres with enhanced stability, and corresponding applications in epigenetics, proteomics and natural product/small molecule diversification ('alkylrandomization').

SUBMITTER: Huber TD

PROVIDER: S-EPMC5138144 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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AdoMet analog synthesis and utilization: current state of the art.

Huber Tyler D TD Johnson Brooke R BR Zhang Jianjun J Thorson Jon S JS

Current opinion in biotechnology 20160806

S-Adenosyl-l-methionine (AdoMet) is an essential enzyme cosubstrate in fundamental biology with an expanding range of biocatalytic and therapeutic applications. In recent years, technologies enabling the synthesis and utilization of novel functional AdoMet surrogates have rapidly advanced. Developments highlighted within this brief review include improved syntheses of AdoMet analogs, unique S-adenosyl-l-methionine isosteres with enhanced stability, and corresponding applications in epigenetics, ...[more]

PMID: 27506965

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