Ontology highlight
ABSTRACT:
SUBMITTER: Marchetti M
PROVIDER: S-EPMC5138847 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Marchetti Marialaura M Liuzzi Anastasia A Fermi Beatrice B Corsini Romina R Folli Claudia C Speranzini Valentina V Gandolfi Francesco F Bettati Stefano S Ronda Luca L Cendron Laura L Berni Rodolfo R Zanotti Giuseppe G Percudani Riccardo R
Scientific reports 20161206
Urate oxidase (Uox) catalyses the first reaction of oxidative uricolysis, a three-step enzymatic pathway that allows some animals to eliminate purine nitrogen through a water-soluble compound. Inactivation of the pathway in hominoids leads to elevated levels of sparingly soluble urate and puts humans at risk of hyperuricemia and gout. The uricolytic activities lost during evolution can be replaced by enzyme therapy. Here we report on the functional and structural characterization of Uox from zeb ...[more]