Ontology highlight
ABSTRACT:
SUBMITTER: Hotz C
PROVIDER: S-EPMC5139637 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Hotz Christian C Treinies Marina M Mottas Ines I Rötzer Laurin C LC Oberson Anne A Spagnuolo Lorenzo L Perdicchio Maurizio M Spinetti Thibaud T Herbst Tina T Bourquin Carole C
Oncoimmunology 20160909 11
Toll-like receptor (TLR) 7 agonists are effective in topical application for the immunotherapy of skin cancers, but their performance for the systemic treatment of solid tumors is limited by the development of TLR tolerance. In this study, we describe a novel strategy to overcome TLR tolerance and enhance TLR7-dependent antitumor immune responses through reprogramming of TLR signaling pathways. The sensitivity of TLR7 signaling in dendritic cells (DC) was increased by prior stimulation with the ...[more]