Biotherapy in the Adjuvant Treatment of Colorectal Cancer.
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ABSTRACT:
SUBMITTER: Tazi EM
PROVIDER: S-EPMC5139728 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
Biotherapy in the Adjuvant Treatment of Colorectal Cancer.
Tazi El Mehdi EM Essadi Ismail I Boutayeb Saber S M'rabti Hind H Errihani Hassan H
Gastroenterology research 20110720 4
The use of adjuvant chemotherapy has improved survival in early-stage colon cancer. Ongoing adjuvant clinical trials are evaluating the addition of targeted therapies to standard chemotherapy regimen. Preliminary results with bevacizumab were disappointing. Also, cetuximab added to chemotherapy does not seem to be better than chemotherapy alone, even in selected wild-type KRAS populations. A better understanding of mechanisms of action of drugs, tumor biology, and predictive biomarkers are neede ...[more]
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