Dataset Information

The Effect of Iron Fortification on Iron (Fe) Status and Inflammation: A Randomized Controlled Trial.

ABSTRACT:

Background

Iron deficiency (ID) is common in toddlers in developing countries. Iron fortified or meat-based complementary foods may be effective to prevent ID.

Objective

Our objective was to compare iron status at 18 months and growth from 6 to 18 months in rural poor toddlers fed 3 different complementary foods.

Methods

The study was nested within a larger trial in which 6-month-old infants were randomized to receive 50g/d meat (MG), an equi-caloric fortified cereal supplement (FG) or local cereal supplement (LG) for 1 year. Hb, sTfR, HsCRP, ferritin and AGP were measured in 410 blood samples collected by a random sampling (MG, 137; FG, 140; LG, 133); calprotectin was measured in feces. Body iron = -[log (sTfR ×1000/ferritin)-2.8229] /0.1207. ID = ferritin<12ug/L.

Results

The toddlers in FG had the significantly highest levels in serum ferritin and body iron (P = 0.043, 0.004), and the rates of both ID and iron deficiency anemia (IDA) were the lowest in FG (P = 0.010, 0.021). The rate of systemic inflammation in FG was 30.71%, which was the highest among three groups (P = 0.042). No intervention effects on either the rates of ID and IDA or iron stores (serum ferritin and body iron) were shown in MG. The change in length-for-age z scores (LAZ) from 6 to 18 months among three groups was significantly different (P = 0.021) and a smaller decrease of LAZ in MG and a larger decrease of LAZ in FG were observed.

Conclusion

Iron fortified cereal improved iron status of poor rural toddlers but was also associated with systemic inflammation which was likely to impair their growth.

SUBMITTER: Ma J

PROVIDER: S-EPMC5140064 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

The Effect of Iron Fortification on Iron (Fe) Status and Inflammation: A Randomized Controlled Trial.

Ma Jingqiu J Sun Qianqian Q Liu Jinrong J Hu Yanqi Y Liu Shanshan S Zhang Jie J Sheng Xiaoyang X Hambidge K Michael KM

PloS one 20161206 12

<h4>Background</h4>Iron deficiency (ID) is common in toddlers in developing countries. Iron fortified or meat-based complementary foods may be effective to prevent ID.<h4>Objective</h4>Our objective was to compare iron status at 18 months and growth from 6 to 18 months in rural poor toddlers fed 3 different complementary foods.<h4>Methods</h4>The study was nested within a larger trial in which 6-month-old infants were randomized to receive 50g/d meat (MG), an equi-caloric fortified cereal supple ...[more]

PMID: 27923057

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Project description:BACKGROUND:Lentils are generally considered to be a nutrient-dense food, and a good source of iron (Fe). This study aims to establish novel evidence of the effectiveness of the consumption of Fe-fortified lentils in improving the body Fe status and thus cognitive performance in non-pregnant adolescent girls in rural Bangladesh, compared to consumption of ordinary lentils. METHODS:We have designed a double-blind (both trial participants and outcome assessors), community-based, cluster-randomized controlled trial among 1260 Bangladeshi adolescent girls between the ages of 10-17?years who are non-smoking, not married, not pregnant, not breastfeeding, and generally healthy at the time of enrollment. The intervention will include three arms who will receive: (1) Fe-fortified lentils; (2) unfortified lentils; or (3) usual intake. Participants will be served a thick preparation of cooked Fe-fortified lentils (37.5?g raw lentils, approximately 200?g cooked lentils) 5?days per week for 85 feeding days (around 4?months) using a locally acceptable recipe. Lentils were fortified with Fe in the laboratory at the Department of Plant Sciences at the University of Saskatchewan in Canada. A subsample of participants (n?=?360) will be randomly invited to be included in cognitive testing. DISCUSSION:Data on socio-demographic characteristics, household food security status, adolescent food habits and cognitive testing will be collected at baseline and endline (4?months). Venous blood samples will be collected at baseline, midline (2?months) and endline to measure adolescents' Fe status. Computerized cognitive testing will include five common measures of attentional (three of attention) and mnemonic functioning (two of memory) carried out using DMDX software. The results of this study will be used to garner support for and to substantiate large-scale production and market expansion of Fe-fortified lentils, and will contribute to knowledge about how to enhance Fe status in adolescents worldwide in resource-poor settings, using staple food crops. TRIAL REGISTRATION:ClinicalTrials.gov NCT03516734 . Registered on 24 May 2018.

Dataset Information

The Effect of Iron Fortification on Iron (Fe) Status and Inflammation: A Randomized Controlled Trial.

Background

Objective

Methods

Results

Conclusion

Publications

The Effect of Iron Fortification on Iron (Fe) Status and Inflammation: A Randomized Controlled Trial.

Similar Datasets

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