Iron acquisition pathways and colonization of the inflamed intestine by Salmonella enterica serovar Typhimurium.
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ABSTRACT:
SUBMITTER: Costa LF
PROVIDER: S-EPMC5140723 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
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Iron acquisition pathways and colonization of the inflamed intestine by Salmonella enterica serovar Typhimurium.
Costa Luciana F LF Mol Juliana P S JP Silva Ana Patricia C AP Macêdo Auricélio A AA Silva Teane M A TM Alves Geraldo E S GE Winter Sebastian S Winter Maria G MG Velazquez Eric M EM Byndloss Mariana X MX Bäumler Andreas J AJ Tsolis Renée M RM Paixão Tatiane A TA Santos Renato L RL
International journal of medical microbiology : IJMM 20161013 8
Salmonella enterica serotype Typhimurium is able to expand in the lumen of the inflamed intestine through mechanisms that have not been fully resolved. Here we utilized streptomycin-pretreated mice and dextran sodium sulfate (DSS)-treated mice to investigate how pathways for S. Typhimurium iron acquisition contribute to pathogen expansion in the inflamed intestine. Competitive infection with an iron uptake-proficient S. Typhimurium strain and mutant strains lacking tonB feoB, feoB, tonB or iroN ...[more]
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