Ontology highlight
ABSTRACT:
SUBMITTER: Babon JA
PROVIDER: S-EPMC5140746 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Babon Jenny Aurielle B JA DeNicola Megan E ME Blodgett David M DM Crèvecoeur Inne I Buttrick Thomas S TS Maehr René R Bottino Rita R Naji Ali A Kaddis John J Elyaman Wassim W James Eddie A EA Haliyur Rachana R Brissova Marcela M Overbergh Lut L Mathieu Chantal C Delong Thomas T Haskins Kathryn K Pugliese Alberto A Campbell-Thompson Martha M Mathews Clayton C Atkinson Mark A MA Powers Alvin C AC Harlan David M DM Kent Sally C SC
Nature medicine 20161031 12
A major therapeutic goal for type 1 diabetes (T1D) is to induce autoantigen-specific tolerance of T cells. This could suppress autoimmunity in those at risk for the development of T1D, as well as in those with established disease who receive islet replacement or regeneration therapy. Because functional studies of human autoreactive T cell responses have been limited largely to peripheral blood-derived T cells, it is unclear how representative the peripheral T cell repertoire is of T cells infilt ...[more]