Ontology highlight
ABSTRACT:
SUBMITTER: Cao D
PROVIDER: S-EPMC5140766 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Cao Dan D Song Xinhua X Che Li L Li Xiaolei X Pilo Maria G MG Vidili Gianpaolo G Porcu Alberto A Solinas Antonio A Cigliano Antonio A Pes Giovanni M GM Ribback Silvia S Dombrowski Frank F Chen Xin X Li Lei L Calvisi Diego F DF
Liver international : official journal of the International Association for the Study of the Liver 20160706 1
<h4>Background & aims</h4>Although it is well established that fatty acids (FA) are indispensable for the proliferation and survival of cancer cells in hepatocellular carcinoma (HCC), inhibition of Fatty Acid Synthase (FASN) cannot completely repress HCC cell growth in culture. Thus, we hypothesized that uptake of exogenous FA by cancer cells might play an important role in the development and progression of HCC. Lipoprotein lipase (LPL) is the enzyme that catalyses the hydrolysis of triglycerid ...[more]