Unknown

Dataset Information

0

Accelerated pseudogenization on the neo-X chromosome in Drosophila miranda.


ABSTRACT: Y chromosomes often degenerate via the accumulation of pseudogenes and transposable elements. By contrast, little is known about X-chromosome degeneration. Here we compare the pseudogenization process between genes on the neo-sex chromosomes in Drosophila miranda and their autosomal orthologues in closely related species. The pseudogenization rate on the neo-X is much lower than the rate on the neo-Y, but appears to be higher than the rate on the orthologous autosome in D. pseudoobscura. Genes under less functional constraint and/or genes with male-biased expression tend to become pseudogenes on the neo-X, indicating the accumulation of slightly deleterious mutations and the feminization of the neo-X. We also find a weak trend that the genes with female-benefit/male-detriment effects identified in D. melanogaster are pseudogenized on the neo-X, implying the masculinization of the neo-X. These observations suggest that both X and Y chromosomes can degenerate due to a complex suite of evolutionary forces.

SUBMITTER: Nozawa M 

PROVIDER: S-EPMC5141340 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Accelerated pseudogenization on the neo-X chromosome in Drosophila miranda.

Nozawa Masafumi M   Onizuka Kanako K   Fujimi Mai M   Ikeo Kazuho K   Gojobori Takashi T  

Nature communications 20161129


Y chromosomes often degenerate via the accumulation of pseudogenes and transposable elements. By contrast, little is known about X-chromosome degeneration. Here we compare the pseudogenization process between genes on the neo-sex chromosomes in Drosophila miranda and their autosomal orthologues in closely related species. The pseudogenization rate on the neo-X is much lower than the rate on the neo-Y, but appears to be higher than the rate on the orthologous autosome in D. pseudoobscura. Genes u  ...[more]

Similar Datasets

| S-EPMC3236567 | biostudies-literature
| S-EPMC6071650 | biostudies-literature
| S-EPMC1207793 | biostudies-other
| S-EPMC2374705 | biostudies-literature
| S-EPMC1698622 | biostudies-literature
| S-EPMC3986819 | biostudies-literature
| S-EPMC49756 | biostudies-other
| S-EPMC2915643 | biostudies-literature
| S-EPMC6849804 | biostudies-literature
| PRJNA277849 | ENA