Ontology highlight
ABSTRACT:
SUBMITTER: Fryknas M
PROVIDER: S-EPMC5141479 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Fryknäs Mårten M Zhang Xiaonan X Bremberg Ulf U Senkowski Wojciech W Olofsson Maria Hägg MH Brandt Peter P Persson Ingmar I D'Arcy Padraig P Gullbo Joachim J Nygren Peter P Schughart Leoni Kunz LK Linder Stig S Larsson Rolf R
Scientific reports 20161207
Poorly vascularized areas of solid tumors contain quiescent cell populations that are resistant to cell cycle-active cancer drugs. The compound VLX600 was recently identified to target quiescent tumor cells and to inhibit mitochondrial respiration. We here performed gene expression analysis in order to characterize the cellular response to VLX600. The compound-specific signature of VLX600 revealed a striking similarity to signatures generated by compounds known to chelate iron. Validation experi ...[more]