Unknown

Dataset Information

0

A low balance between microparticles expressing tissue factor pathway inhibitor and tissue factor is associated with thrombosis in Behcet's Syndrome.

ABSTRACT: Thrombosis is common in Behçet's Syndrome (BS), and there is a need for better biomarkers for risk assessment. As microparticles expressing Tissue Factor (TF) can contribute to thrombosis in preclinical models, we investigated whether plasma microparticles expressing Tissue Factor (TF) are increased in BS. We compared blood plasma from 72 healthy controls with that from 88 BS patients (21 with a history of thrombosis (Th+) and 67 without (Th-). Using flow cytometry, we found that the total plasma MP numbers were increased in BS compared to HC, as were MPs expressing TF and Tissue Factor Pathway Inhibitor (TFPI) (all p?0.7 had a history of clinical thrombosis. We conclude that TF-expressing MP are increased in BS and that an imbalance between microparticulate TF and TFPI may predispose to thrombosis.

SUBMITTER: Khan E 

PROVIDER: S-EPMC5141484 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

A low balance between microparticles expressing tissue factor pathway inhibitor and tissue factor is associated with thrombosis in Behçet's Syndrome.

Khan E E   Ambrose N L NL   Ahnström J J   Kiprianos A P AP   Stanford M R MR   Eleftheriou D D   Brogan P A PA   Mason J C JC   Johns M M   Laffan M A MA   Haskard D O DO  

Scientific reports 20161207

Thrombosis is common in Behçet's Syndrome (BS), and there is a need for better biomarkers for risk assessment. As microparticles expressing Tissue Factor (TF) can contribute to thrombosis in preclinical models, we investigated whether plasma microparticles expressing Tissue Factor (TF) are increased in BS. We compared blood plasma from 72 healthy controls with that from 88 BS patients (21 with a history of thrombosis (Th+) and 67 without (Th-). Using flow cytometry, we found that the total plasm  ...[more]

Similar Datasets

Unknown Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis.
| S-EPMC6776793 | biostudies-literature
Unknown Tissue factor expressed by circulating cancer cell-derived microparticles drastically increases the incidence of deep vein thrombosis in mice.
| S-EPMC4496280 | biostudies-literature
Unknown Platelet tissue factor pathway inhibitor-α dampens cardiac thrombosis and associated fibrosis in mice.
| S-EPMC10200073 | biostudies-literature
Unknown Tissue factor-expressing tumor cells can bind to immobilized recombinant tissue factor pathway inhibitor under static and shear conditions in vitro.
| S-EPMC4388665 | biostudies-literature
Unknown Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis.
| S-EPMC2947398 | biostudies-literature
Unknown Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency.
| S-EPMC2572790 | biostudies-literature
Unknown Clusters in Behcet's syndrome.
| S-EPMC9617315 | biostudies-literature
Unknown Beyond thrombosis: the impact of tissue factor signaling in cancer.
| S-EPMC7362520 | biostudies-literature
Unknown Musculoskeletal manifestations in children with Behcet's syndrome: data from the AIDA Network Behcet's Syndrome Registry.
| S-EPMC10082129 | biostudies-literature
Unknown Behcet's syndrome: providing integrated care.
| S-EPMC5565245 | biostudies-other