Ontology highlight
ABSTRACT:
SUBMITTER: Castellanos-Gonzalez A
PROVIDER: S-EPMC5142094 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Castellanos-Gonzalez Alejandro A Sparks Hayley H Nava Samantha S Huang Wenlin W Zhang Zhongsheng Z Rivas Kasey K Hulverson Matthew A MA Barrett Lynn K LK Ojo Kayode K KK Fan Erkang E Van Voorhis Wesley C WC White Arthur Clinton AC
The Journal of infectious diseases 20161012 12
Cryptosporidium is recognized as one of the main causes of childhood diarrhea worldwide. However, the current treatment for cryptosporidiosis is suboptimal. Calcium flux is essential for entry in apicomplexan parasites. Calcium-dependent protein kinases (CDPKs) are distinct from protein kinases of mammals, and the CDPK1 of the apicomplexan Cryptosporidium lack side chains that typically block a hydrophobic pocket in protein kinases. We exploited this to develop bumped kinase inhibitors (BKIs) th ...[more]