MAPT haplotype H1G is associated with increased risk of dementia with Lewy bodies.
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ABSTRACT:
SUBMITTER: Labbe C
PROVIDER: S-EPMC5143206 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
MAPT haplotype H1G is associated with increased risk of dementia with Lewy bodies.
Labbé Catherine C Heckman Michael G MG Lorenzo-Betancor Oswaldo O Soto-Ortolaza Alexandra I AI Walton Ronald L RL Murray Melissa E ME Allen Mariet M Uitti Ryan J RJ Wszolek Zbigniew K ZK Smith Glenn E GE Kantarci Kejal K Knopman David S DS Lowe Val J VJ Jack Clifford R CR Ertekin-Taner Nilüfer N Hassan Anhar A Savica Rodolfo R Petersen Ronald C RC Parisi Joseph E JE Maraganore Demetrius M DM Graff-Radford Neill R NR Ferman Tanis J TJ Boeve Bradley F BF Dickson Dennis W DW Ross Owen A OA
Alzheimer's & dementia : the journal of the Alzheimer's Association 20160607 12
<h4>Introduction</h4>The MAPT H1 haplotype has been associated with several neurodegenerative diseases. We were interested in exploring the role of MAPT haplotypic variation in risk of dementia with Lewy bodies (DLB).<h4>Method</h4>We genotyped six MAPT haplotype tagging SNPs and screened 431 clinical DLB cases, 347 pathologically defined high-likelihood DLB cases, and 1049 controls.<h4>Result</h4>We performed haplotypic association tests and detected an association with the protective H2 haplot ...[more]
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