Ontology highlight
ABSTRACT:
SUBMITTER: Bozzi AT
PROVIDER: S-EPMC5143219 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Bozzi Aaron T AT Bane Lukas B LB Weihofen Wilhelm A WA Singharoy Abhishek A Guillen Eduardo R ER Ploegh Hidde L HL Schulten Klaus K Gaudet Rachelle R
Structure (London, England : 1993) 20161110 12
The widely conserved natural resistance-associated macrophage protein (Nramp) family of divalent metal transporters enables manganese import in bacteria and dietary iron uptake in mammals. We determined the crystal structure of the Deinococcus radiodurans Nramp homolog (DraNramp) in an inward-facing apo state, including the complete transmembrane (TM) segment 1a (absent from a previous Nramp structure). Mapping our cysteine accessibility scanning results onto this structure, we identified the me ...[more]