Ontology highlight
ABSTRACT:
SUBMITTER: Hinze F
PROVIDER: S-EPMC5143357 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Hinze Florian F Dieterich Christoph C Radke Michael H MH Granzier Henk H Gotthardt Michael M
Journal of molecular medicine (Berlin, Germany) 20161126 12
Impaired diastolic filling is a main contributor to heart failure with preserved ejection fraction (HFpEF), a syndrome with increasing prevalence and no treatment. Both collagen and the giant sarcomeric protein titin determine diastolic function. Since titin's elastic properties can be adjusted physiologically, we evaluated titin-based stiffness as a therapeutic target. We adjusted RBM20-dependent cardiac isoform expression in the titin N2B knockout mouse with increased ventricular stiffness. A ...[more]