Ontology highlight
ABSTRACT:
SUBMITTER: Yan J
PROVIDER: S-EPMC5143403 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Yan J J Wang L L Wang Z Z Wang Z Z Wang B B Zhu R R Bi J J Wu J J Zhang H H Wu H H Yu B B Kong W W Yu X X
Cell death & disease 20160623 6
Successful cancer therapies aim to induce selective apoptosis in neoplastic cells. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered an attractive anticancer agent due to its tumor cell-specific cytotoxicity. However, earlier studies with recombinant TRAIL revealed many shortcomings, including a short half-life, off-target toxicity and existence of TRAIL-resistant tumor cells. In this study, we developed a novel engineering strategy for recombinant soluble TRAIL by re ...[more]