Ontology highlight
ABSTRACT:
SUBMITTER: Sun WS
PROVIDER: S-EPMC5143739 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Sun Wu-Sheng WS Chun Ju-Lan JL Do Jeong-Tae JT Kim Dong-Hwan DH Ahn Jin-Seop JS Kim Min-Kyu MK Hwang In-Sul IS Kwon Dae-Jin DJ Hwang Seong-Soo SS Lee Jeong-Woong JW
Stem cells international 20161124
Oct4 is a crucial germ line-specific transcription factor expressed in different pluripotent cells and downregulated in the process of differentiation. There are two conserved enhancers, called the distal enhancer (DE) and proximal enhancer (PE), in the 5' upstream regulatory sequences (URSs) of the mouse <i>Oct4</i> gene, which were demonstrated to control <i>Oct4</i> expression independently in embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs). We analyzed the URSs of the pig <i>Oct ...[more]