Unknown

Dataset Information

0

Lipid-modified G4-decoy oligonucleotide anchored to nanoparticles: delivery and bioactivity in pancreatic cancer cells.


ABSTRACT: KRAS is mutated in >90% of pancreatic ductal adenocarcinomas. As its inactivation leads to tumour regression, mutant KRAS is considered an attractive target for anticancer drugs. In this study we report a new delivery strategy for a G4-decoy oligonucleotide that sequesters MAZ, a transcription factor essential for KRAS transcription. It is based on the use of palmitoyl-oleyl-phosphatidylcholine (POPC) liposomes functionalized with lipid-modified G4-decoy oligonucleotides and a lipid-modified cell penetrating TAT peptide. The potency of the strategy in pancreatic cancer cells is demonstrated by cell cytometry, confocal microscopy, clonogenic and qRT-PCR assays.

SUBMITTER: Cogoi S 

PROVIDER: S-EPMC5144097 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3786135 | biostudies-literature
| S-EPMC8585332 | biostudies-literature
| S-EPMC5006671 | biostudies-literature
| S-EPMC8353930 | biostudies-literature
| S-EPMC3366963 | biostudies-literature
| S-EPMC7911392 | biostudies-literature
| S-EPMC5045320 | biostudies-literature
| S-EPMC8107723 | biostudies-literature
| S-EPMC9416266 | biostudies-literature
| S-EPMC7261218 | biostudies-literature