Ontology highlight
ABSTRACT:
SUBMITTER: Fraser SD
PROVIDER: S-EPMC5144133 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Fraser Simon D SD Sadofsky Laura R LR Kaye Paul M PM Hart Simon P SP
Scientific reports 20161208
In sarcoidosis, the proinflammatory cytokines interferon gamma, tumour necrosis factor and interleukin-6 are released by monocyte-derived macrophages and lymphocytes in the lungs and other affected tissues. Regulatory receptors expressed on monocytes and macrophages act to suppress cytokine production, and reduced expression of regulatory receptors may thus promote tissue inflammation. The aim of this study was to characterise the role of regulatory receptors on blood monocytes in patients with ...[more]