Ontology highlight
ABSTRACT:
SUBMITTER: Sanada Y
PROVIDER: S-EPMC5144138 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Sanada Yohei Y Yamamoto Takafumi T Satake Rika R Yamashita Akiko A Kanai Sumire S Kato Norihisa N van de Loo Fons Aj FA Nishimura Fusanori F Scherer Philipp E PE Yanaka Noriyuki N
Scientific reports 20161208
The infiltration of macrophages into adipose tissue and their interaction with adipocytes are essential for the chronic low-grade inflammation of obese adipose tissue. In this study, we identified the serum amyloid A3 (Saa3) gene as a key adipocyte-derived factor that is affected by interaction with macrophages. We showed that the Saa3 promoter in adipocytes actually responds to activated macrophages in a co-culture system. Decreasing C/EBPβ abundance in 3T3-L1 adipocytes or point mutation of C/ ...[more]