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Efficacy and tolerability of the modified Atkins diet in young children with refractory epilepsy: Indian experience.


ABSTRACT: BACKGROUND:The modified Atkins diet (MAD) has been used predominantly in older children, adolescents, and adults. There is a paucity of data on the use of the MAD in refractory epilepsy in young children. OBJECTIVES:This study was planned to evaluate the efficacy and tolerability of the MAD in refractory epilepsy in young children. METHODS:This study recruited children aged 9 months to 3 years with refractory seizures. Children received MAD for 6-month with the on-going anticonvulsant medications being continued unchanged. Reduction in seizure frequency was the primary outcome measure. Adverse effects were also studied. RESULTS:Thirty-one children with daily seizures were studied with a median age of 18-month (range 9-30 months). West syndrome was the most common epilepsy syndrome (26, 86.6%). Twenty-one children remained on diet at 3 months and 13 at 6 months. The children who achieved >50% seizure reduction were 17 (54.8%) at 3 months and 9 (29%) at 6 months. Refusal to eat was a significant problem seen in eight children. Three children discontinued the diet due to adverse effects. CONCLUSION:The MAD was found to be feasible, effective, and well-tolerated.

SUBMITTER: Mehta R 

PROVIDER: S-EPMC5144480 | biostudies-literature | 2016 Oct-Dec

REPOSITORIES: biostudies-literature

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Efficacy and tolerability of the modified Atkins diet in young children with refractory epilepsy: Indian experience.

Mehta Ranju R   Goel Shaiphali S   Sharma Suvasini S   Jain Puneet P   Mukherjee Sharmila B SB   Aneja Satinder S  

Annals of Indian Academy of Neurology 20161001 4


<h4>Background</h4>The modified Atkins diet (MAD) has been used predominantly in older children, adolescents, and adults. There is a paucity of data on the use of the MAD in refractory epilepsy in young children.<h4>Objectives</h4>This study was planned to evaluate the efficacy and tolerability of the MAD in refractory epilepsy in young children.<h4>Methods</h4>This study recruited children aged 9 months to 3 years with refractory seizures. Children received MAD for 6-month with the on-going ant  ...[more]

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