Misoprostol for treating postpartum haemorrhage: a randomized controlled trial [ISRCTN72263357].

ABSTRACT: BACKGROUND: Postpartum haemorrhage remains an important cause of maternal death despite treatment with conventional therapy. Uncontrolled studies and one randomised comparison with conventional oxytocics have reported dramatic effects with high-dose misoprostol, usually given rectally, for treatment of postpartum haemorrhage, but this has not been evaluated in a placebo-controlled trial. METHODS: The study was conducted at East London Hospital Complex, Tembisa and Chris Hani Baragwanath Hospitals, South Africa. Routine active management of the third stage of labour was practised. Women with more than usual postpartum bleeding thought to be related to inadequate uterine contraction were invited to participate, and to sign informed consent. All routine treatment was given from a special 'Pos

SUBMITTER: Hofmeyr GJ 

PROVIDER: S-EPMC514549 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature