Ontology highlight
ABSTRACT:
SUBMITTER: Nunes RR
PROVIDER: S-EPMC5146734 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Nunes Renata Rachide RR Costa Marina Dos Santos MD Santos Bianca Dos Reis BD Fonseca Amanda Luisa da AL Ferreira Lorena Sales LS Chagas Rafael Cesar Russo RC Silva Alisson Marques da AM Varotti Fernando de Pilla FP Taranto Alex Gutterres AG
Memorias do Instituto Oswaldo Cruz 20161110 12
The main challenge in the control of malaria has been the emergence of drug-resistant parasites. The presence of drug-resistant Plasmodium sp. has raised the need for new antimalarial drugs. Molecular modelling techniques have been used as tools to develop new drugs. In this study, we employed virtual screening of a pyrazol derivative (Tx001) against four malaria targets: plasmepsin-IV, plasmepsin-II, falcipain-II, and PfATP6. The receiver operating characteristic curves and area under the curve ...[more]