Ontology highlight
ABSTRACT:
SUBMITTER: Song N
PROVIDER: S-EPMC5146928 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Song Nana N Guan Ruijuan R Jiang Qian Q Hassanzadeh Comron J CJ Chu Yuyang Y Zhao Xiaomei X Wang Xia X Yang Dawei D Du Qijun Q Chu Xiang-Ping XP Shen Linlin L
Scientific reports 20161209
The role of acid-sensing ion channels (ASICs) in the ventrolateral medulla (VLM) remains uncertain. Here, we found that ASIC1a and ASIC2 are widely expressed in rat medulla, and the expression level is higher at neonatal stage as compared to adult stage. The two ASIC subunits co-localized in medualla neurons. Furthermore, pH reduction triggered typical ASIC-type currents in the medulla, including the VLM. These currents showed a pH<sub>50</sub> value of 6.6 and were blocked by amiloride. Based o ...[more]