Ontology highlight
ABSTRACT:
SUBMITTER: Yap LF
PROVIDER: S-EPMC5146930 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Yap Lee Fah LF Lai Sook Ling SL Patmanathan Sathya Narayanan SN Gokulan Ravindran R Robinson C Max CM White Joe B JB Chai San Jiun SJ Rajadurai Pathmanathan P Prepageran Narayanan N Liew Yew Toong YT Lopes Victor V Wei Wenbin W Hollows Robert J RJ Murray Paul G PG Lambert Daniel W DW Hunter Keith D KD Paterson Ian C IC
Scientific reports 20161209
Head and neck squamous cell carcinoma (HNSCC) is generalized term that encompasses a diverse group of cancers that includes tumours of the oral cavity (OSCC), oropharynx (OPSCC) and nasopharynx (NPC). Genetic alterations that are common to all HNSCC types are likely to be important for squamous carcinogenesis. In this study, we have investigated the role of the homeodomain-only homeobox gene, HOPX, in the pathogenesis of HNSCC. We show that HOPX mRNA levels are reduced in OSCC and NPC cell lines ...[more]