Unknown

Dataset Information

0

High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform.


ABSTRACT: With great advances in the field of in vitro brain modelling, the challenge is now to implement these technologies for development and evaluation of new drug candidates. Here we demonstrate a method for culturing three-dimensional networks of spontaneously active neurons and supporting glial cells in a microfluidic platform. The high-throughput nature of the platform in combination with its compatibility with all standard laboratory equipment allows for parallel evaluation of compound effects.

SUBMITTER: Wevers NR 

PROVIDER: S-EPMC5146966 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6546835 | biostudies-literature
| S-EPMC4650750 | biostudies-literature
| S-EPMC5979969 | biostudies-literature
| S-EPMC4334502 | biostudies-literature
| S-EPMC7712835 | biostudies-literature
| S-EPMC8166820 | biostudies-literature
| S-EPMC4814922 | biostudies-literature
| S-EPMC4636036 | biostudies-literature
| S-EPMC5087404 | biostudies-literature
| S-EPMC7019623 | biostudies-literature