High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform.
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ABSTRACT: With great advances in the field of in vitro brain modelling, the challenge is now to implement these technologies for development and evaluation of new drug candidates. Here we demonstrate a method for culturing three-dimensional networks of spontaneously active neurons and supporting glial cells in a microfluidic platform. The high-throughput nature of the platform in combination with its compatibility with all standard laboratory equipment allows for parallel evaluation of compound effects.
SUBMITTER: Wevers NR
PROVIDER: S-EPMC5146966 | biostudies-literature |
REPOSITORIES: biostudies-literature
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