Ontology highlight
ABSTRACT:
SUBMITTER: Mani RS
PROVIDER: S-EPMC5147555 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Mani Ram S RS Amin Mohammad A MA Li Xiangyi X Kalyana-Sundaram Shanker S Veeneman Brendan A BA Wang Lei L Ghosh Aparna A Aslam Adam A Ramanand Susmita G SG Rabquer Bradley J BJ Kimura Wataru W Tran Maxwell M Cao Xuhong X Roychowdhury Sameek S Dhanasekaran Saravana M SM Palanisamy Nallasivam N Sadek Hesham A HA Kapur Payal P Koch Alisa E AE Chinnaiyan Arul M AM
Cell reports 20161201 10
Approximately 50% of prostate cancers are associated with gene fusions of the androgen-regulated gene TMPRSS2 to the oncogenic erythroblast transformation-specific (ETS) transcription factor ERG. The three-dimensional proximity of TMPRSS2 and ERG genes, in combination with DNA breaks, facilitates the formation of TMPRSS2-ERG gene fusions. However, the origins of DNA breaks that underlie gene fusion formation in prostate cancers are far from clear. We demonstrate a role for inflammation-induced o ...[more]