Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen TQ
PROVIDER: S-EPMC5147747 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Nguyen Thu Q TQ Alqurafi Maha M Edwards Cash C Nguyen Pauline P Kim Jean J Casco Samuel S Bennet Maricka M Chiang Christopher C Lohry Maureen M Cox Melina M Meshram Byron B Le Duyen D Kim Eugene E Smriti Snigdha S Oelschlaeger Peter P Buynak John D JD
Tetrahedron letters 20160616 30
Although α-diazo-β-ketoesters are synthetically versatile intermediates, methodology for introducing this functionality into complex molecules is still limited, most frequently involving a carboxylic acid precursor, which is then activated and transformed into a β-ketoester, with the diazo group being subsequently added with a diazo transfer reagent. While introducing this highly functional moiety in a convergent one step process would be ideal, such an objective is limited by the relatively few ...[more]