Ontology highlight
ABSTRACT:
SUBMITTER: Ben-Moshe Livne Z
PROVIDER: S-EPMC5147766 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Ben-Moshe Livne Zohar Z Alon Shahar S Vallone Daniela D Bayleyen Yared Y Tovin Adi A Shainer Inbal I Nisembaum Laura G LG Aviram Idit I Smadja-Storz Sima S Fuentes Michael M Falcón Jack J Eisenberg Eli E Klein David C DC Burgess Harold A HA Foulkes Nicholas S NS Gothilf Yoav Y
PLoS genetics 20161121 11
The master circadian clock in fish has been considered to reside in the pineal gland. This dogma is challenged, however, by the finding that most zebrafish tissues contain molecular clocks that are directly reset by light. To further examine the role of the pineal gland oscillator in the zebrafish circadian system, we generated a transgenic line in which the molecular clock is selectively blocked in the melatonin-producing cells of the pineal gland by a dominant-negative strategy. As a result, c ...[more]