Pleiotropic Mechanisms Indicated for Sex Differences in Autism.
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ABSTRACT:
SUBMITTER: Mitra I
PROVIDER: S-EPMC5147776 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Pleiotropic Mechanisms Indicated for Sex Differences in Autism.
Mitra Ileena I Tsang Kathryn K Ladd-Acosta Christine C Croen Lisa A LA Aldinger Kimberly A KA Hendren Robert L RL Traglia Michela M Lavillaureix Alinoë A Zaitlen Noah N Oldham Michael C MC Levitt Pat P Nelson Stanley S Amaral David G DG Hertz-Picciotto Irva I Fallin M Daniele MD Weiss Lauren A LA
PLoS genetics 20161115 11
Sexual dimorphism in common disease is pervasive, including a dramatic male preponderance in autism spectrum disorders (ASDs). Potential genetic explanations include a liability threshold model requiring increased polymorphism risk in females, sex-limited X-chromosome contribution, gene-environment interaction driven by differences in hormonal milieu, risk influenced by genes sex-differentially expressed in early brain development, or contribution from general mechanisms of sexual dimorphism sha ...[more]
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