Dataset Information

Malaria in HIV-Infected Children Receiving HIV Protease-Inhibitor- Compared with Non-Nucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy, IMPAACT P1068s, Substudy to P1060.

ABSTRACT:

Background

HIV and malaria geographically overlap. HIV protease inhibitors kill malaria parasites in vitro and in vivo, but further evaluation in clinical studies is needed.

Methods

Thirty-one children from Malawi aged 4-62 months were followed every 3 months and at intercurrent illness visits for ?47 months (September 2009-December 2011). We compared malaria parasite carriage by blood smear microscopy (BS) and confirmed clinical malaria incidence (CCM, or positive BS with malaria symptoms) in children initiated on HIV antiretroviral therapy (ART) with zidovudine, lamivudine, and either nevirapine (NVP), a non-nucleoside reverse transcriptase inhibitor, or lopinavir-ritonavir (LPV-rtv), a protease inhibitor.

Results

We found an association between increased time to recurrent positive BS, but not CCM, when anti-malarial treatment and LPV-rtv based ART were used concurrently and when accounting for a LPV-rtv and antimalarial treatment interaction (adjusted HR 0.39; 95% CI (0.17,0.89); p = 0.03).

Conclusions

LPV-rtv in combination with malaria treatment was associated with lower risk of recurrent positive BS, but not CCM, in HIV-infected children. Larger, randomized studies are needed to confirm these findings which may permit ART optimization for malaria-endemic settings.

Trial registration

ClinicalTrials.gov NCT00719602.

SUBMITTER: Hobbs CV

PROVIDER: S-EPMC5147802 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Malaria in HIV-Infected Children Receiving HIV Protease-Inhibitor- Compared with Non-Nucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy, IMPAACT P1068s, Substudy to P1060.

Hobbs Charlotte V CV Gabriel Erin E EE Kamthunzi Portia P Tegha Gerald G Tauzie Jean J Petzold Elizabeth E Barlow-Mosha Linda L Chi Benjamin H BH Li Yonghua Y Ilmet Tiina T Kirmse Brian B Neal Jillian J Parikh Sunil S Deygoo Nagamah N Jean Philippe Patrick P Mofenson Lynne L Prescott William W Chen Jingyang J Musoke Philippa P Palumbo Paul P Duffy Patrick E PE Borkowsky William W

PloS one 20161209 12

<h4>Background</h4>HIV and malaria geographically overlap. HIV protease inhibitors kill malaria parasites in vitro and in vivo, but further evaluation in clinical studies is needed.<h4>Methods</h4>Thirty-one children from Malawi aged 4-62 months were followed every 3 months and at intercurrent illness visits for ≤47 months (September 2009-December 2011). We compared malaria parasite carriage by blood smear microscopy (BS) and confirmed clinical malaria incidence (CCM, or positive BS with malaria ...[more]

PMID: 27936233

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Dataset Information

Malaria in HIV-Infected Children Receiving HIV Protease-Inhibitor- Compared with Non-Nucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy, IMPAACT P1068s, Substudy to P1060.

Background

Methods

Results

Conclusions

Trial registration

Publications

Malaria in HIV-Infected Children Receiving HIV Protease-Inhibitor- Compared with Non-Nucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy, IMPAACT P1068s, Substudy to P1060.

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