Dataset Information

Angiogenic proteins, placental weight and perinatal outcomes among pregnant women in Tanzania.

ABSTRACT:

Introduction

Placental vascular development, and ultimately placental weight, is essential to healthy fetal development. Here, we examined placental weight in a cohort of Tanzanian women in association with angiogenic proteins known to regulate placental vascular development and perinatal outcomes.

Methods

A total of n = 6579 women with recorded placental weight were included in this study. The relative risk of adverse perinatal outcomes (Apgar score, death, asphyxia, respiratory distress, seizures, pneumonia and sepsis) was compared between placental weight in the bottom and top 10th percentiles. We quantified angiogenic mediators (Ang-1, Ang-2, VEGF, PGF and sFlt-1) in plasma samples (n = 901) collected between 12 to 27 weeks of pregnancy using ELISA and assessed the relative risk of placental weight in the bottom and top 10th percentiles by protein levels in quartiles.

Results

Women with Ang-2 levels in the highest quartile had an increased relative risk of placental weight in the bottom 10th percentile (RR = 1.45 (1.10, 1.91), p = 0.01). Women with VEGF-A (RR = 0.73 (0.56, 0.96), p = 0.05) and PGF (RR = 0.58 (0.44, 0.72), p = 0.002) in the highest quartile had a reduced relative risk of placental weight in the bottom 10th percentile. Low placental weight (in bottom 10th percentile) was associated with an increased relative risk of Apgar score of <7 at 1 minute (RR = 2.31 (1.70, 3.13), p = 0.001), at 5 minutes (RR = 3.53 (2.34, 5.33), p = 0.001), neonatal death (RR = 5.02 (3.61, 7.00), p = 0.001), respiratory distress (RR = 4.80(1.71, 13.45), p = 0.001), and seizures (RR = 4.18 (1.16, 15.02), p = 0.03).

Discussion

The association between low placental weight and risk of adverse perinatal outcomes in this cohort suggests that placental weight could serve as a useful indicator, providing additional insight into high-risk pregnancies and identifying neonates that may require additional monitoring and follow-up.

SUBMITTER: McDonald CR

PROVIDER: S-EPMC5147955 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Angiogenic proteins, placental weight and perinatal outcomes among pregnant women in Tanzania.

McDonald Chloe R CR Darling Anne M AM Liu Enju E Tran Vanessa V Cabrera Ana A Aboud Said S Urassa Willy W Kain Kevin C KC Fawzi Wafaie W WW

PloS one 20161209 12

<h4>Introduction</h4>Placental vascular development, and ultimately placental weight, is essential to healthy fetal development. Here, we examined placental weight in a cohort of Tanzanian women in association with angiogenic proteins known to regulate placental vascular development and perinatal outcomes.<h4>Methods</h4>A total of n = 6579 women with recorded placental weight were included in this study. The relative risk of adverse perinatal outcomes (Apgar score, death, asphyxia, respiratory ...[more]

PMID: 27936130

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Dataset Information

Angiogenic proteins, placental weight and perinatal outcomes among pregnant women in Tanzania.

Introduction

Methods

Results

Discussion

Publications

Angiogenic proteins, placental weight and perinatal outcomes among pregnant women in Tanzania.

Similar Datasets

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